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Chronic hepatitis B and C [electronic resource]

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The scope of the book is very broad, covering a wide range of areas in HBV/HDV and HCV research, including both basic and clinical science. The selected topics range from epidemiology, immunology, molecular virology and oncology, to clinical therapy.Chronic Hepatitis B and C consists of 14 chapters, each being a review of a special topic on HBV or HCV. While review articles on a special topic can be found in periodical journals, they tend to be more restricted in presentation. Therefore, this book will provide more in-depth coverage of what are presented as "unpublished results" and "data not

כותר Chronic hepatitis B and C [electronic resource] : basic science to clinical applications / editor, Chiaho Shih.
מוציא לאור Singapore
Hackensack, NJ : World Scientific
שנה c2013
הערות Description based upon print version of record.
Includes bibliographical references and index.
English
הערת תוכן ותקציר Preface
Foreword
Contents
Contributors
Hepatitis B Virus
Chapter 1 Natural Course of Chronic Hepatitis B Virus Infection Chia-Ming Chu and Yun-Fan Liaw
Introduction
Epidemiology of Chronic HBV Infection
Clinical Presentation
Phases of Chronic HBV Infection
Immune Tolerant Phase
Immune Clearance Phase
Hepatitis Activity and Acute Hepatitis Flares (HBeAg-positive Chronic Hepatitis) during Immune Clearance Phase
HBeAg to anti-HBe Seroconversion
HBeAg Persistence and Its Outcome
Inactive/Residual Phase
Spontaneous HBsAg Seroclearance
Reactivation of Hepatitis B
HBeAg Reversion
HBeAg-Negative Chronic HepatitisConcurrent Viral Superinfection as Part of Natural Course
Hepatitic C Virus
Hepatitis D Virus
Human Immunodeficiency Virus
Sequelae and Mortality
Cirrhosis and Contributing Factors
Hepatic Decompensation and Mortality
HCC and Contributing Factors
Survival of Cirrhosis
Conclusion
References
Chapter 2 Immune Response and Viral Hepatitis B David R. Milich
Serology of Acute and Chronic HBV Infections
The PreS Envelope Antigens
Increased Complexity of the Serology of Chronic HBV Infection
Human T Cell Responses in Acute and Chronic HBV InfectionCD4 + Th Cell Response
CD8 + CTL Response
Innate Immunity to HBV
Mechanisms of Liver Injury and Clearance
Transgenic Models of Immune-mediated Liver Injury
HBV Persistence
Tolerogenicity of HBc/HBeAgs
Immune Escape Variants
Manifestations of HBV-Specific T Cell Tolerance
Immunogenetics
Summary
Acknowledgment
Chapter 3 Epidemiology of Viral Hepatitis B-related Hepatocellular Carcinoma Katherine A. McGlynn, Alison A. Evans and W. Thomas London
History
Global Prevalence of Chronic HBV Infection
Liver Cancer Incidence, Mortality, and SurvivalDemographic Factors
Age
Sex
Ethnicity
Risk Factors
Aflatoxin
Alcohol
Tobacco
Pesticides
Iron-related Conditions
Endogenous and Exogenous Hormones
Host Susceptibility
Susceptibility to Chronic HBV Infection
Susceptibility to HCC Once Chronic HBV Infection is Established
Viral Factors
Viral Load
Viral Genotype
Viral Mutations
HBV and Other Cancers
Future Directions and Unresolved Issues
Chapter 4 Molecular Biology of HBV-related Hepatocellular Carcinoma Amanda J. Hodgson and Betty L. Slagle
Abstract
Lessons from Other Tumor VirusesHBV and HCC
A Model for HBV-associated HCC
Immune-mediated Pathogenesis
Early Immune Response to HBV Infection
Immune-mediated Clearance of HBV
Immune Pathogenesis During Chronic Infection
Effect of HBx on Liver Regeneration
Liver Regeneration in HBV Transgenic Mice
Role of Viral Integration in HCC
General Features of HBV Integration
Lessons Learned from the WHV System
HBV Integration in Human HCCs
Potential Oncogenic Properties of HBV Gene Products
PreS1
PreS2 Truncations
Regulatory HBx Protein
HBx and the Cell Cycle
Activation of Signal Transduction Pathways
היקף החומר 1 online resource (415 p.)
שפה אנגלית
מספר מערכת 997010713154505171
תצוגת MARC

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