Home care : origin, organization and present status of the extra-mural program of Montegiore Hospital.
Montefiore Hospital for Chronic Diseases
BookThe scope of the book is very broad, covering a wide range of areas in HBV/HDV and HCV research, including both basic and clinical science. The selected topics range from epidemiology, immunology, molecular virology and oncology, to clinical therapy.Chronic Hepatitis B and C consists of 14 chapters, each being a review of a special topic on HBV or HCV. While review articles on a special topic can be found in periodical journals, they tend to be more restricted in presentation. Therefore, this book will provide more in-depth coverage of what are presented as "unpublished results" and "data not
Title |
Chronic hepatitis B and C [electronic resource] : basic science to clinical applications / editor, Chiaho Shih. |
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Publisher |
Singapore Hackensack, NJ : World Scientific |
Creation Date |
c2013 |
Notes |
Description based upon print version of record. Includes bibliographical references and index. English |
Content |
Preface Foreword Contents Contributors Hepatitis B Virus Chapter 1 Natural Course of Chronic Hepatitis B Virus Infection Chia-Ming Chu and Yun-Fan Liaw Introduction Epidemiology of Chronic HBV Infection Clinical Presentation Phases of Chronic HBV Infection Immune Tolerant Phase Immune Clearance Phase Hepatitis Activity and Acute Hepatitis Flares (HBeAg-positive Chronic Hepatitis) during Immune Clearance Phase HBeAg to anti-HBe Seroconversion HBeAg Persistence and Its Outcome Inactive/Residual Phase Spontaneous HBsAg Seroclearance Reactivation of Hepatitis B HBeAg Reversion HBeAg-Negative Chronic HepatitisConcurrent Viral Superinfection as Part of Natural Course Hepatitic C Virus Hepatitis D Virus Human Immunodeficiency Virus Sequelae and Mortality Cirrhosis and Contributing Factors Hepatic Decompensation and Mortality HCC and Contributing Factors Survival of Cirrhosis Conclusion References Chapter 2 Immune Response and Viral Hepatitis B David R. Milich Serology of Acute and Chronic HBV Infections The PreS Envelope Antigens Increased Complexity of the Serology of Chronic HBV Infection Human T Cell Responses in Acute and Chronic HBV InfectionCD4 + Th Cell Response CD8 + CTL Response Innate Immunity to HBV Mechanisms of Liver Injury and Clearance Transgenic Models of Immune-mediated Liver Injury HBV Persistence Tolerogenicity of HBc/HBeAgs Immune Escape Variants Manifestations of HBV-Specific T Cell Tolerance Immunogenetics Summary Acknowledgment Chapter 3 Epidemiology of Viral Hepatitis B-related Hepatocellular Carcinoma Katherine A. McGlynn, Alison A. Evans and W. Thomas London History Global Prevalence of Chronic HBV Infection Liver Cancer Incidence, Mortality, and SurvivalDemographic Factors Age Sex Ethnicity Risk Factors Aflatoxin Alcohol Tobacco Pesticides Iron-related Conditions Endogenous and Exogenous Hormones Host Susceptibility Susceptibility to Chronic HBV Infection Susceptibility to HCC Once Chronic HBV Infection is Established Viral Factors Viral Load Viral Genotype Viral Mutations HBV and Other Cancers Future Directions and Unresolved Issues Chapter 4 Molecular Biology of HBV-related Hepatocellular Carcinoma Amanda J. Hodgson and Betty L. Slagle Abstract Lessons from Other Tumor VirusesHBV and HCC A Model for HBV-associated HCC Immune-mediated Pathogenesis Early Immune Response to HBV Infection Immune-mediated Clearance of HBV Immune Pathogenesis During Chronic Infection Effect of HBx on Liver Regeneration Liver Regeneration in HBV Transgenic Mice Role of Viral Integration in HCC General Features of HBV Integration Lessons Learned from the WHV System HBV Integration in Human HCCs Potential Oncogenic Properties of HBV Gene Products PreS1 PreS2 Truncations Regulatory HBx Protein HBx and the Cell Cycle Activation of Signal Transduction Pathways |
Extent |
1 online resource (415 p.) |
Language |
English |
National Library system number |
997010713154505171 |
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