חזרה לתוצאות החיפוש

Recent advances in psoriasis [electronic resource]

להגדלת הטקסט להקטנת הטקסט
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This book presents the evidence for the belief that psoriasis is a disease of abnormal keratinocyte proliferation induced by T cells. The latest approaches to investigating the immunopathogenesis of this disease, and a review of previous findings, are presented to give an overall picture of the current knowledge in this field. Each topic is discussed in detail, clearly illustrated and well referenced. The book should prove invaluable to clinical dermatologists, and researchers in the fields of immunology and dermatology who have an interest in skin diseases.

כותר Recent advances in psoriasis [electronic resource] : the role of the immune system / Barbara S. Baker.
מוציא לאור London : Imperial College Press
River Edge, N.J. : Distributed by World Scientific Pub. Co.
שנה c2000
הערות Description based upon print version of record.
Includes bibliographical references and index.
English
הערת תוכן ותקציר Preface
Contents
CHAPTER 1 Aetiology, Clinical and Histological Features of Psoriasis
1.1 Clinical Features
1.2 Genetics
1.2.1 Epidemiology
1.2.2 Mode of Inheritance
1.2.3 Genomic Imprinting
1.2.4 HLA Associations
1.2.5 Gene Linkage
1.2.6. Candidate Genes
1.3 Environmental Factors
1.4 Histological Features
References
CHAPTER 2 Skin Immune System in Psoriasis
2.1 Skin Immune System (SIS)
2.2 T Cell Subpopulations: Normal Skin
2.3 T Cell Subpopulations: Psoriatic Skin
2.4 Antigen-Presenting Cells: Normal Skin
2.4.1 Epidermal Dendritic Cells
2.4.2 Dermal Dendritic Cells (DDC)
2.4.3 Indeterminate Cells2.4.4 Macrophages
2.5 Antigen-Presenting Cells: Psoriatic Skin
2.5.1 Epidermal Dendritic Cells
2.5.2 Dermal Dendritic Cells (DDQ
2.6 Endothelial Cells
2.7 Neutrophils
2.8 Mast Cells
2.9 Keratinocytes
CHAPTER 3 Immune Cell Function in Psoriasis
3.1 T Lymphocytes: Peripheral Blood
3.2 T Lymphocytes: Skin
3.2.1 T Cell Homing
3.2.2 T Cell Proliferation
3.2.3 Cytokine Production
3.3 Antigen-Presenting Cells
3.3.1 Epidermal Dendritic Cells
3.3.2 Dermal Dendritic Cells (DDC)
CHAPTER 4 Psoriasis is aT Cell-Mediated Disease
4.1 Anti-Psoriatic Treatments4.2 Anti-CD4 Monoclonal Antibodies
4.3 Lymphocyte-Selective Toxin (DAB389IL-2
4.4 SCID Mouse Models
4.5 Bone-Marrow Transplantation
4.6 T Cell Supernatants Promote Keratinocyte Proliferation
4.7 Low CD4+/HIV Infection
CHAPTER 5 β Haemolytic Streptococci and Psoriasis
5.1 Group A Streptococci as a Trigger for Guttate Psoriasis
5.2 Group A Streptococci and CP Psoriasis
5.3 Induction of Psoriatic Lesions by Streptococci
5.4 Streptococcal Antigens
5.4.1 Extracellular Products
5.4.1.1 Streptococcal pyrogenic exotoxins (SPEs)
5.4.1.2 Streptococcal cytolytic toxins (haemolysins)5.4.1.3 Streptococcal enzymes
5.4.2 Cellular Proteins
5.4.2.1 M and M-like proteins
5.4.2.2 Other cell wall proteins
5.4.2.3 Membrane proteins
5.5 Immune Response to Extracellular Streptococcal Proteins and Superantigens
5.5.1 Humoral Response
5.5.2 In Vivo/In Vitro Response to SK/SD
5.5.3 Superantigens
5.6 Immune Response to Streptococcal Cellular Proteins
5.6.1 Streptococcal Cell Walls and Membranes
5.6.2 Streptococcal M Protein
5.6.3 Streptococcal Membrane Proteins
5.6.4 CLA Induction by Group A Streptococcal Antigens
ReferencesCHAPTER 6 Immune Function of Psoriatic Keratinocytes
6.1 Cytokine Production
6.1.1 Interleukin-1 (IL-1)
6.1.2 Interleukin-6 (IL-6)
6.1.3 Interleukin-7 (IL-7)
6.1.4 Interleukin-8 (IL-8)
6.1.5 Interleukin-10 (1L-10)
6.1.6 Interleukin-12 (IL-12)
6.1.7 Interleukin-15 (IL-15) and Interleukin-18 (IL-18)
6.1.8 Tumour Necrosis Factor-a (TNF-a)
6.1.9 Growth Factors
6.1.9.1 Transforming growth factor-a (TGF-a)/Evidermal growth factor (EGF)
6.1.9.1 Transforming growth factor-a (TGF-α)/Evidermal growth factor (EGF)
6.1.9.2 Amphiregulin (AR)/Heparin-binding EGF-like growth factor (HB-EGF)
היקף החומר 1 online resource (186 p.)
שפה אנגלית
מספר מערכת 997010713607105171
תצוגת MARC

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