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Molecular imaging probes for cancer research [electronic resource]
להגדלת הטקסט להקטנת הטקסט- ספר
This review volume integrates the advances in cancer biology, molecular imaging techniques and imaging probes for visualization and quantitative measurement of anatomical, functional, and molecular profiles of cancer. The volume also presents a comprehensive summary of the state-of-the-art technology in molecular imaging probe design and applications in radionuclide (PET and SPECT), magnetic resonance (MR), optical (fluorescence, Raman, photoacoustic), ultrasound, CT, and multimodality imaging. Bringing together the fundamentals of molecular imaging, and the basic principles of each molecular
| כותר |
Molecular imaging probes for cancer research [electronic resource] / edited by Xiaoyuan Chen. |
|---|---|
| מוציא לאור |
Singapore : World Scientific |
| שנה |
c2012 |
| הערות |
Description based upon print version of record. Includes bibliographical references and index. English |
| הערת תוכן ותקציר |
Contents List of Contributors Preface Session I: Fundamentals of Molecular Imaging Chapter 1 Introduction to Cancer Biology Ramasamy Paulmurugan 1. Introduction 2. Genetics of Cancer Cells 2.1. Molecular mechanisms in normal and cancer cells 3. Incidence of Cancer 4. Cancer Cells and Tissues 5. Biological Networks in Regulating the Cellular Signaling Pathways 6. Focus on Diagnostic and Therapeutic Strategies for Cancer 6.1. Preventive cancer vaccines 6.2. Therapeutic cancer vaccines 7. Molecular Imaging Tools for the Early Diagnosis of Cancer 7.1. Ultrasound (Ultrasonography) 7.2. Computerized tomography (CT)7.3. Magnetic resonance imaging (MRI) 7.4. PET and SPECT 8. Drug Development for Cancer Treatment 8.1. Molecular therapeutic targets of cancer cells 8.2. Molecularly targeted therapy using small molecule drugs 8.3. Antibody-mediated inhibition of receptor tyrosine kinases 9. Cancer Treatment by Targeting Death Receptors 10. Future Approaches in Cancer Diagnostics and Therapeutics References Chapter 2 Molecular Imaging Instrumentation Craig S. Levin 2. Positron Emission Tomography (PET) 2.1. Introduction 2.2. PET instrumentation 2.3. PET methodology2.4. PET system performance issues 2.5. Advances in PET system technology 3. Single Photon Emission Computed Tomography (SPECT) 3.1. Introduction 3.2. SPECT instrumentation 3.3. SPECT methodology 3.4. SPECT System Performance Issues 3.5. Advances in SPECT System Technology 4. Optical Fluorescence Imaging (FLI) 4.1. Introduction 4.2. Tissue optical properties: Absorption and scatter of light 4.3. Optical versus radionuclide imaging 4.4. Optical versus radionuclide tomography 4.5. FLI instrumentation 4.6. FLI methodology 4.7. FLI system performance issues 4.8. FLI versus BLI4.9. Advances in non-invasive in vivo FLI system technology 4.10. Invasive in vivo FL microscopy methods 5. Magnetic Resonance Imaging (MRI) 5.1. Introduction 5.2. Basics of nuclear magnetic resonance (NMR) 5.3. MRI instrumentation 5.4. MRI methodology 5.5. MRI performance issues 6. Multiple Modality Molecular Imaging of Living Subjects 7. Can Molecular Imaging Instrumentation be Further Improved? Enhance contrast resolution: Increase signal and reduce background Advance spatial resolution Improve molecular imaging signal quantification Chapter 3 Molecular Imaging Data Analysis F. Habte1. Introduction 2. General Concepts, Notation and Terminology 2.1. Image formation 2.2. Image basics 2.2.1. Pixel and voxel 2.2.2. Matrix size and spatial resolution 2.2.3. Pixel value and depth 2.2.4. Image representation and file formats 2.3. Image display 3. Image Quality 3.1. Definition and metrics 3.2. Contrast 3.3. Resolution 3.4. Noise 3.5. Artifacts and distortion 4. Image Data Acquisition Process 4.1. Acquisition workflow 4.2. Image acquisition options 4.3. Image types and dimensions 5. Image Processing and Visualization |
| היקף החומר |
1 online resource (1102 p.) |
| שפה |
אנגלית |
| מספר מערכת |
997010712986405171 |
תצוגת MARC
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