כניסה עם גוגל
כניסה עם פייסבוק
The Association between cocaine exposure duration, BDNF levels in specific brian regions and addactive-like behaviors of the rat / Amit Shai ; under the supervision of: Abraham Zangen.
Amit Shai author
עבודת מחקרבחרו את שפת העמוד:
שפה נוכחית
Cocaine abuse [electronic resource]
להגדלת הטקסט להקטנת הטקסט- ספר
Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of behavioral, pharmacological, and neurobiological determinants. While a complete understanding of cocaine abuse is currently beyond us, significant progress has been made in preclinical research on fundamental determinants of this disorder. These advances are critically reviewed in the first section of this volume. Important advances also have
| כותר |
Cocaine abuse [electronic resource] : behavior, pharmacology, and clinical applications / [edited by] Stephen T. Higgins, Jonathan L. Katz. |
|---|---|
| מוציא לאור |
San Diego : Academic Press |
| שנה |
c1998 |
| הערות |
Description based upon print version of record. Includes bibliographical references and index. English |
| הערת תוכן ותקציר |
Front Cover Cocaine Abuse: Behavior, Pharmacology, and Clinical Applications Copyright Page Contents Contributors Foreword Preface Chapter 1. Basic Pharmacological Mechanisms of Cocaine Introduction Regulation of Transporter Function Neurochemical Effects of Cocaine Measured in Vivo Acute and Chronic Effects of Cocaine on Receptors Molecular Mechanisms of Cocaine Effects Summary References Chapter 2. Neuroanatomical Bases of the Reinforcing Stimulus Effects of Cocaine The Mesoaccumbens Ascending Dopaminergic Pathway The Medial Prefrontal Cortex The Amygdala's Role in Behavioral Effects of Self-Administered Cocaine Newly Charted Territories: Subiculum, Basal Nucleus, and Pedunculopontine Summary and Implications for Cortico-Striato-Pallido-Thalamic Circuitry Chapter 3. Behavioral Pharmacology of Cocaine and the Determinants of Abuse Liability Psychomotor-Stimulant Effects of Cocaine Interoceptive Effects of Cocaine Contextual Determinants of the Reinforcing Effects of Cocaine Alternatives to Cocaine Self-Administration Suppression of Cocaine-Maintained Responding Chapter 4. Behavioral-Environmental Determinants of the Reinforcing Functions of Cocaine Introduction Evaluation of Cocaine Reinforcement Experimental Events Modulating Cocaine Reinforcement Environmental Context Processes Modulating Reinforcement Chapter 5. Tolerance and Sensitization to Cocaine: An Integrated View Tolerance Sensitization Tolerance and Sensitization in Cocaine Abuse Chapter 6. Preclinical Evaluation of Pharmacotherapies for Cocaine Abuse Drug Discrimination Intravenous Drug Self-Administration Antibodies to Cocaine Conclusions Chapter 7. Prenatal Exposure to Cocaine Case Studies Epidemiological Studies Nonhuman Experimental Studies Conclusions Chapter 8. Cocaine Self-Administration Research: Implications for Rational Pharmacotherapy Ethical and Safety Issues Involved in Administering Cocaine to Humans Assessing Cocaine Self-Administration in Human Research Participants The Use of Cocaine Self-Administration Procedures to Inform Cocaine Pharmacotherapy Conclusion Chapter 9. Evaluation of Potential Pharmacotherapies: Response to Cocaine Challenge in the Human Laboratory Introduction Mechanisms of Pharmacotherapy Approaches to Pharmacotherapy Development Studies of Potential Pharmacotherapies Using the Laboratory Challenge Method Chapter 10. Controlled Laboratory Studies on the Effects of Cocaine in Combination with Other Commonly Abused Drugs in Humans Patterns of Multiple Drug Abuse among Cocaine Abusers Cocaine-Alcohol Combinations Cocaine-Opioid Combinations Cocaine-Marijuana Combinations Cocaine-Nicotine Combinations |
| היקף החומר |
1 online resource (471 p.) |
| שפה |
אנגלית |
| מספר מערכת |
997010710568105171 |
תצוגת MARC
יודעים עוד על הפריט? זיהיתם טעות?
