Th17 cells
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- Work cat.: Chu, Cong-Qiu. Targeting the IL-17 Pathway in Inflammatory Disorders, 2017:Back cover ("IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. The discovery of the IL-17/Th17 pathway has seen exciting development in the field of immunology and inflammation research, which has led to a number of recent regulatory approvals")
- Annals of Dermatology, October 2017:p. 578 (Article title: "A Study of the Changes of T Helper 17 Cells and Regulatory T Cells in Herpes Zoster")
- The Multifaceted Role of Th17 Lymphocytes and Their Associated Cytokines in Cancer (Abstract: "While the role of T helper 17 lymphocytes (Th17) in the pathogenesis of autoimmune diseases and in infectious immunity has been relatively well defined, the impact of these cells and their associated cytokines on cancer development is still under debate" ( (Clinical and Developmental Immunology, 2013:) )
- MeSH, March 15, 2018(T17 cells; scope note: Scope NoteA subset of helper-effector T-lymphocytes which synthesize and secrete INTERLEUKINS IL-17; IL-17F; and IL-22. These cytokines are involved in host defenses and tissue inflammation in autoimmune diseases; entry terms: T Helper 17 Cells, TH-17 Cells, Type 17 Helper T Cells)
Wikipedia description:
T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17). They are related to T regulatory cells and the signals that cause Th17s to actually inhibit Treg differentiation. However, Th17s are developmentally distinct from Th1 and Th2 lineages. Th17 cells play an important role in maintaining mucosal barriers and contributing to pathogen clearance at mucosal surfaces; such protective and non-pathogenic Th17 cells have been termed as Treg17 cells. They have also been implicated in autoimmune and inflammatory disorders. The loss of Th17 cell populations at mucosal surfaces has been linked to chronic inflammation and microbial translocation. These regulatory Th17 cells can be generated by TGF-beta plus IL-6 in vitro.
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