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Introduction to drug designing and development
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This book is useful to readers who are just beginning in the field of drug design and development. It starts with an introduction and some basic information about drugs. Pharmacokinetic and pharmacodynamic aspects are covered in the initial chapters. Systemic descriptions of pharmacokinetic parameters such as absorption, distribution, metabolism, and excretion are explained in simple and easy language. This book demonstrates detailed concepts of lead molecules and their sources. In addition, drug target classification, identification and validation strategies, as well as the design and develop
| Title |
Introduction to drug designing and development / Rajnish Kumar, Anju Sharma and Rajesh Kumar Tiwari, editors. |
|---|---|
| Publisher |
New York : Nova Science Publishers |
| Creation Date |
[2014] |
| Notes |
Description based upon print version of record. Includes bibliographical references and index. English |
| Content |
""INTRODUCTION TO DRUG DESIGNING AND DEVELOPMENT"" ""INTRODUCTION TO DRUG DESIGNING AND DEVELOPMENT"" ""Library of Congress Cataloging-in-Publication Data"" ""Contents"" ""Preface"" ""Acknowledgment"" ""Contributors"" ""Chapter 1 Drugs: Introduction and Definition"" ""Abstract"" ""Introduction"" ""History"" ""Basic Terminologies Related to Drugs"" ""Drug Nomenclature"" ""Adverse Effects of Drugs"" ""Classification of Drugs"" ""References"" ""Chapter 2 Pharmacokinetics"" ""ADME Properties"" ""Rates of Reaction"" ""Models Associated with Pharmacokinetics""""Absorption"" ""Distribution"" ""Metabolism"" ""Elimination"" ""Chapter 3 Pharmacodynamics"" ""Drug Receptor Theory"" ""Occupation Theory"" ""Mechanism of Drug Action"" ""Chapter 4 Plants As a Source of Lead Molecules"" ""1. Introduction"" ""2. System of Medicines"" ""3. Plant Metabolites"" ""4. Classification of Secondary Metabolites"" ""5. Terpenoids"" ""6. Alkaloids"" ""7. Non-Protein Amino Acids (NPAA�s)"" ""8. Polyketides"" ""9. Polyacetylenes"" ""Conclusion"" ""References""""Chapter 5 Animals As a Source of Lead Molecules"" ""Terrestrial Animals as Drug Resource"" ""Marine Organism as Drug Resource"" ""Impact of Indiscreet Animal Application for Medicinal Purposes"" ""Future of Animals as Drug Resource"" ""Chapter 6 Drug Targets and ValidationTechniques"" ""What Are Drug Targets?"" ""Characteristics of Drug Targets"" ""Classification of Drug Targets"" ""Drug Target Identification"" ""Direct Biochemical Methods"" ""Genetic Interaction Methods"" ""Computational Inference Methods""""Drug Target Validation"" ""Chapter 7 Screening of Drugs"" ""ADME Property"" ""Virtual Screening"" ""Methods of Virtual Screening"" ""Chapter 8 Structure-Based Drug Designing"" ""Methods that Analyze the Active Site"" ""Methods That Dock Whole Molecule"" ""Connection Methods"" ""Chapter 9 Concepts of Combinatorial Library"" ""2. Combinatorial Chemistry Approaches"" ""3. Library Requirements"" ""4. Experimental Techniques in Combinatorial Chemistry""""5. Screening of Combinatorial Libraries"" ""Chapter 10 Quantitative Structure Activity Relationship"" ""2. Molecular Structure and Molecular Properties"" ""3. QSAR Equations"" ""4. Molecular Descriptors"" ""5. Free Wilson Analysis"" ""6. QSAR Modeling"" ""7. Three Dimensional (3D) Qsar"" ""8. Difference between Traditional QSAR and 3DQSAR"" ""Chapter 11 Pharmacophore Modeling"" ""Summary"" ""History of Pharmacophore"" ""Pharmacophore Based Drug Designing"" ""Golden Rule of Six"" |
| Series |
Pharmacology - research, safety testing and regulation |
| Extent |
1 online resource (224 p.) |
| Language |
English |
| Copyright Date |
©2014 |
| National Library system number |
997010713359705171 |
MARC RECORDS
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