Multiple sclerosis and related disorders

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  • كتاب

Multiple Sclerosis and Related Disorders provides evidence-based data and experience-based guidance for delivering quality long-term care to MS patients. Information on disease history, pathophysiology, and biology is included to provide clinicians with a framework for understanding current diagnosis, monitoring, and treatment strategies for these disorders. In addition to thoroughly reviewing the newest disease-modifying treatments, the authors have devoted significant focus to the symptoms that frequently manifest and their treatment options. Symptoms and functional limitations are the ""fac

العنوان Multiple sclerosis and related disorders : clinical guide to diagnosis, medical management, and rehabilitation / editors, Alexander D. Rae-Grant, Robert J. Fox, Francois Bethoux.
الطبعة 1st ed.
الناشر New York : Demos Medical
تاريخ الإصدار c2013
ملاحظات Description based upon print version of record.
Includes bibliographical references and index.
English.
رقم الرف Cover
Title
Copyright
Contents
Contributors
Foreword
Preface
Part I. Basics for Clinicians
1. History of Multiple Sclerosis
Early Cases of MS
Early Descriptions of MS
Description by Charcot
Early Monographs
Early Reports
Three Landmark Reviews of MS
Theories About Causation
Search for an Infection
Epidemiology
Genetics of MS
Vascular Theory
The Immunological Theory
MS Plaque
Investigations
Cognitive Changes in MS
Therapy
Multiple Sclerosis Societies
References
2. Overview of Multiple Sclerosis
New Directions in Understanding MS
New Directions in Diagnosing MS
New Directions in Monitoring MSNew Directions in Treatment of MS Disease Activity
New Directions in Treatment of MS Symptoms
Greater Recognition of The Importance of Other Health Measures in MS
Embracing a Team Approach To MS
Ongoing Challenges and Future Promise
Bibliography
3. Pathology and Pathophysiology of Multiple Sclerosis
Demyelination within GM and WM in MS
Inflammation in MS
WM Inflammation in MS
GM Inflammation in MS
Neuronal and Axonal degeneration in MS
Pathophysiology of Neurodegeneration in MS
Summary
4. Epidemiology and Natural History of Multiple SclerosisEpidemiology, Survival, Incidence, and Prevalence of Multiple Sclerosis
Environmental Risk Factors for MS
The Natural History of MS
Environmental Risk Factors and The Natural History of MS
Benign MS
5. Multiple Sclerosis Genetics
Race and Geography
Familial Aggregation
The First Molecular Markers for MS: Human Leukocyte Antigens
Linkage Analysis
MS as A Complex Trait
Genomic Linkage Screens
Missing Heritability
Vitamin D Genetics
Exome and Genome Sequencing
The MHC and MS Susceptibility
Current Directions and LimitationsReferences
Part II. Diagnosis
6. Symptoms and Signs of Multiple Sclerosis
Illustrative Case
Introduction
Evaluation of Symptoms
Symptom Review by System
Nonspecific Versus Specific Symptoms
Conclusion-Finding Patterns Which Fit Together
7. Diagnosis of Multiple Sclerosis
Diagnostic Criteria: A Very Short History
Diagnosing MS: The Mcdonald Criteria (2010)
Defining The Phenomenology of MS
Putting The Mcdonald Criteria (2010) Into Practice
Diagnosing MS by Combined Clinical and MRI Criteria
The Utility of Cerebrospinal Fluid Examination in the Diagnosis of MS: Why Do a Lumbar Puncture?Diagnostic Categories Resulting from Applying the Mcdonald Criteria
Limitations of the Mcdonald (2010) Criteria
Future Directions in the Diagnosis of MS
8. Magnetic Resonance Imaging in Multiple Sclerosis
Relevant MRI Physics
Characterization of MS on Conventional MRI
Technical Considerations and Pitfalls
Clinical Applications in Disease Monitoring
MRI Safety
9. Tools and Tests for Multiple Sclerosis
Blood Tests
Lumbar Puncture/Spinal Fluid Analysis
Evoked Potentials
الشكل 1 online resource (xiv, 325 pages) : illustrations
اللغة الانكليزية
رقم النظام 997010700994505171
MARC RECORDS

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